产品货号：
Z11750
中文名称：
BCAS2抗体
英文名称：
Anti-BCAS2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BCAS2 Antibody |
| 指标别名 | BCAS2;DAM1;Pre mRNA splicing factor SPF27 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | BCAS2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | BCAS2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human BCAS2.The immunogen is located within the last 50 amino acids of BCAS2. |
| 计算分子量 | 26kDa |
| 成分 | BCAS2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | BCAS2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines.The chromosomal region containing this gene,1p13.3021,is amplified in these cells lines.BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression,and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage.Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells,but causes G2-M arrest in p53-null or -mutant cells;this effect was reversed with the expression of ectopic BCAS2.BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer. |
| Uniprot ID | O75934 |
| 基因名全称 | Breast carcinoma amplified sequence 2 |
| 蛋白名全称 | Breast carcinoma amplified sequence 2 |
| 推荐稀释比 | BCAS2 antibody can be used for detection of BCAS2 by Western blot at 0.5 ～ 1μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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